On September 20, 2019, Yu, Miao; Strotman, Neil A.; Savage, Scott A.; Leung, Simon; Ramirez, Antonio published an article.Reference of Pyridine-3-sulfonic acid The title of the article was A Practical and Robust Multistep Continuous Process for Manufacturing 5-Bromo-N-(tert-butyl)pyridine-3-sulfonamide. And the article contained the following:
A multistep continuous flow process involving (1) magnesium-halogen exchange, (2) sulfonylation with sulfuryl chloride, and (3) reaction with tert-butylamine was developed for the synthesis of an arylsulfonamide pharmaceutical intermediate in the synthesis of BMS-919373. The process was successfully implemented, including a robust control strategy to manage the levels of several process impurities, to produce 76 kg of 5-bromo-N-(tert-butyl)pyridine-3-sulfonamide (I). As the instability of the reactive intermediates and existence of strong exotherms made a batch process unsuitable for production beyond a 1 kg scale, the alternative continuous process led to a practical and robust manufacturing route to the active pharmaceutical ingredient. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Reference of Pyridine-3-sulfonic acid
The Article related to bromo tertbutyl pyridine sulfonamide preparation multistep continuous process, magnesium halogen exchange sulfonylation amination continuous flow, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of Pyridine-3-sulfonic acid