On March 24, 2009, Yuan, Chester Chenguang published a patent.Name: 6-(tert-Butyl)pyridin-3-amine The title of the patent was Preparation of substituted arylamine derivatives, particularly 2-aminonicotinamides, as antitumor agents. And the patent contained the following:
The invention is related to the preparation of a compound or a pharmaceutically acceptable derivative thereof, wherein the compound is 3-[(7-isoquinolinyl)amino]-N-[3-methyl-4-(1-methylethyl)phenyl]-3-pyridinecarboxamide are prepared and to its use as an effective agent for treatment of angiogenesis and related diseases such as cancer. Thus, acylation of 7-amino-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-Bu ester with 2-chloropyridine-3-carbonyl chloride, followed by amination of the chloride intermediate (no data) with 7-aminoisoquinoline and deprotection gave 2-[(7-isoquinolinyl)amino]-N-(1,2,3,4-tetrahydro-4,4-dimethyl-7-isoquinolinyl)-3-piperidinecarboxamide monohydrochloride. Selected compounds of the invention inhibited VEGF-stimulated HUVEC proliferation at a level below 1 μM. In the tumor model, compounds of the invention are active at doses less than 150 mpk. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Name: 6-(tert-Butyl)pyridin-3-amine
The Article related to arylamine preparation antitumor angiogenesis inhibitor, pyridinecarboxamide amino preparation neoplasm vegf inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: 6-(tert-Butyl)pyridin-3-amine