Yuan, Qianjia; Prater, Matthew B.; Sigman, Matthew S. published the artcile< Enantioselective Synthesis of γ-Functionalized Cyclopentenones and β-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy>, Electric Literature of 1416819-91-4, the main research area is gamma functionalized cyclopentenone enantioselective preparation; cyclopentenone aryl boronic acid alkenyl triflate palladium relay Heck; delta functionalized cycloheptenone enantioselective preparation; cycloheptenone aryl boronic acid alkenyl triflate palladium relay Heck; Asymmetric Catalysis; C–C Coupling; Heck Reaction; Palladium.
In this report, the desymmetrization of cyclic enones under relay Heck conditions with an array of aryl boronic acids, alkenyl triflates and indole derivatives was described. This method granted facile access to diverse γ-functionalized cyclopentenones I [Ar = Ph, 2-naphthyl, benzo[d][1,3]dioxol-5-yl, 4-oxocyclopent-2-en-1-yl, etc.] and δ-functionalized cycloheptenones II [R = Ph, 4-CF3C6H4, C(Me):C(Me)CO2Et, etc.]. Using this approach, a formal synthesis of (S)-baclofen was completed in high yield and excellent enantioselectivity.
Advanced Synthesis & Catalysis published new progress about Alkylation catalysts. 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Electric Literature of 1416819-91-4.