Yuan, Zi-Qing-Yun published the artcileImpact of 14 types of genetic polymorphisms on antihypertensive efficacy of felodipine in healthy Chinese subjects, Product Details of C18H19Cl2NO4, the main research area is felodipine genetic polymorphism antihypertensive efficacy.
This study evaluated different influences of 14 single nucleotide polymorphisms (SNPs) and demog. factors leading to individual differences in the antihypertensive efficacy of felodipine in healthy Chinese subjects. 24 Subjects were sequenced for candidate SNPs. Plasma samples were obtained as clin. trial protocol, and were determined by a HPLC-MS/MS method. Pharmacokinetic parameters were calculated by WinNonlin 6.0. Statistical anal. was mainly performed by SPSS 22.0. A multiple linear regression model provided different weight coefficients of different demog. and genetic factors. The trend of Cmax is almost consistent with AUCss increase, but tmax of individuals is different; the antihypertensive effect of felodipine is individually different. A significant association was observed between systolic blood pressure decrease (δSBP) and SNPs of CACNA1C, CACNA1D, GNB3 resp., while CACNA1C and CACNA1 were associated with diastolic blood pressure decrease (δDBP). CYP3A5 rs766746 and CYP3A4 rs2242480 were linked with Cmax and AUCss, and ABCB1 rs1045642 was associated with T1/2. Significant relationships were shown between AUCss and ΔSBP (p = 0.022) as well as Cmax and ΔSBP (p = 0.015). The efficacy of felodipine is individually different, influenced especially by CACNA1C rs1051375 and ABCB1 rs1045642. δDBP is associated with δSBP in multiple-dosing of felodipine in healthy Chinese subjects.
International Journal of Clinical Pharmacology and Therapeutics published new progress about Antihypertensives. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Product Details of C18H19Cl2NO4.