Zadymova, N. M. published the artcileNanoemulsions Containing Incorporated Lipophilic Drug, Felodipine, and Microheterogeneous Adhesive Polymer Matrices Based on These Nanoemulsions, SDS of cas: 72509-76-3, the main research area is lipophilic felodipine microheterogeneous adhesive polymer matrix nanoemulsion.
Oil-in-water nanoemulsions (NEs) have been obtained with a simple composition, in which a lipophilic non-micelle-forming nonionic surfactant (Tween 85) serves as both a dispersed phase and a stabilizer. The NEs remain in a metastable state for a long time (several months) and have a highly developed sp. surface area (Ssp ≃ 63 m2/g) and a high solubilization capacity with respect to a lipophilic hypotensive drug, felodipine (FD). Nanosized droplets (dav ≃ 95 nm) of the NEs efficiently transport FD in an aqueous medium. The oil-in-water NEs of Tween 85 with incorporated FD and a solution of a polymer adhesive (a blend of polyisobutylenes having different mol. weights and polybutene) in heptane have been used to obtain oil1/water/oil2 double emulsions, which are used as premixes for polymer microheterogeneous matrixes. Obtained polymer films are characterized by a good adhesion to skin, the absence of FD crystallization, and a constant rate of its release for several hours.
Colloid Journal published new progress about Aggregation. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, SDS of cas: 72509-76-3.