Reference of 2,6-DibromopyridineIn 2020 ,《Tuning Second Coordination Sphere Interactions in Polypyridyl-Iron Complexes to Achieve Selective Electrocatalytic Reduction of Carbon Dioxide to Carbon Monoxide》 was published in Inorganic Chemistry. The article was written by Zee, David Z.; Nippe, Michael; King, Amanda E.; Chang, Christopher J.; Long, Jeffrey R.. The article contains the following contents:
The development of noble-metal-free catalysts capable of electrochem. converting CO2 (CO2) selectively into value-added compounds remains one of the central challenges in catalysis research. Here, the authors present a systematic study of Fe(II) complexes of the functionalized ligands bpyRPY2Me (bpyPY2Me = 6-(1,1-bis(pyridin-2-yl)ethyl)-2,2′-bipyridine) in the pursuit of H2O-stable mol. Fe complexes that are selective for the catalytic formation of CO from CO2. Taking advantage of the inherently high degree of tunability of this ligand manifold, the authors followed a bioinspired approach by installing protic functional groups of varying acidities (-H, -OH, -OMe, -NHEt, and -NEt2) into the ligand framework to systematically modify the 2nd coordination sphere of the Fe center. This family of [(bpyRPY2Me)FeII] complexes was characterized using single-crystal x-ray anal., 1H NMR spectroscopy, and mass spectrometry. Comparative catalytic evaluation of this set of compounds via voltammetry and electrolysis experiments identified [(bpyNHEtPY2Me)Fe]2+ in particular as an efficient, Fe-based, nonheme CO2 electroreduction catalyst that displays significant selectivity for the conversion of CO2 to CO in MeCN solution with 11 M H2O. Probably the NH group acts as a local proton source for cleaving the C-O bond in CO2 to form CO. The complex with the most acidic functional group in the 2nd coordination sphere, [(bpyOHPY2Me)Fe]2+, favors formation of H2 over CO. The authors’ results correlate the selectivity of H2O vs. CO2 reduction to the acidity of the 2nd coordination sphere functional group and emphasize the continued untapped potential that synthetic mol. chem. offers in the pursuit of next-generation CO2 reduction electrocatalysts. The 2nd coordination sphere is systematically altered in polypyridyl-Fe(II) complexes, [(bpyRPY2Me)FeII]2+, with protic functional groups of varying acidities (R = -H, -OH, -OMe, -NHEt, -NEt2). [(BpyNHEtPY2Me)Fe]2+ is an efficient CO2 electroreduction catalyst that is selective for the conversion of CO2 to CO in MeCN solution with 11 M H2O. The complex with the most acidic functional group in the 2nd coordination sphere, [(bpyOHPY2Me)Fe]2+, favors formation of H2 over CO. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Reference of 2,6-Dibromopyridine)
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 2,6-Dibromopyridine