《Constructing antibacterial polymer nanocapsules based on pyridine quaternary ammonium salt》 was written by Zeng, Minghao; Xu, Jiayun; Luo, Quan; Hou, Chunxi; Qiao, Shanpeng; Fu, Shuang; Fan, Xiaotong; Liu, Junqiu. COA of Formula: C6H4N2This research focused ontrispyridyl triazine dibromoethane copolymer nanocapsule preparation antibacterial; Antibacterial; Cationic polymer nanocapsule; Pyridine quaternary ammonium salt. The article conveys some information:
Excessive use of antibiotics accelerates the development and spread of drug-resistant strains, which is a huge challenge for the field of medical health worldwide. Quaternary ammonium salt polymers are considered to be membrane-active bactericidal groups with vast potential to control bacterial infections and inhibit drug resistance. Herein, we report on the creative synthesis and characterization of novel antimicrobial polymer nanocapsules based on pyridine quaternary ammonium salt. The antimicrobial polymer nanocapsules were formed by reaction of C3 sym. rigid monomer 2,4,6-tris(4-pyridyl)-1,3,5-triazine (TPT) and a flexible linker 1,2-dibromoethane. The polymer nanocapsule was constructed as a cationic hollow sphere composed of a two-dimensional sheet whose main chain was formed by the pyridine quaternary ammonium salt, and a part of the bromide ion was adsorbed on the sphere. This hollow nanocapsule was characterized in detail by DLS, SEM, TEM, AFM, EDS and EA. When the cationic polymer nanocapsules are close to the Gram-neg. Escherichia coli, the neg. charged phospholipid mols. in the bacterial membrane are attracted to the cationic surface and lead to rupture of cells. SEM confirmed the breakage of Escherichia coli membranes. The min. inhibitory concentration was found to be 0.04 mg/mL, and the min. bactericidal concentration was 0.1 mg/mL. Our experiments demonstrated that the adsorption of neg. charged phospholipid mols. on the surface of the pyridine quaternary ammonium salt polymer can kill Gram-neg. bacteria without inserting quaternary ammonium salt hydrophobic groups into the cell membrane. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.COA of Formula: C6H4N2