Palladium-Catalyzed Direct C(sp2)-H Alkoxylation of 2-Aryloxypyridines Using 2-Pyridyloxyl as the Directing Group was written by Zhang, Chun;Sun, Peipei. And the article was included in Journal of Organic Chemistry in 2014.SDS of cas: 4783-68-0 This article mentions the following:
An efficient and highly regioselective palladium-catalyzed ortho-C(sp2)-H bond alkoxylation of 2-aryloxypyridines was developed using 2-pyridyloxyl as the directing group and alcs. as alkoxylation reagents. Under an air atm. and in the presence of PhI(OAc)2, the reaction gave the corresponding products in moderate to good yields, and a series of functional groups could be tolerated. E.g., in the presence of Pd(OAc)2 and PhI(OAc)2, regioselective alkoxylation of 2-aryloxypyridine derivative (I) with MeOH gave 58% II. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0SDS of cas: 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 4783-68-0