Formula: C7H9NOIn 2018 ,《Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols》 appeared in Organic Letters. The author of the article were Zhang, Hong; Ruiz-Castillo, Paula; Buchwald, Stephen L.. The article conveys some information:
Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcs. For activated substrates, such as electron-deficient aryl halides, the com. available ligand I [R = R’ = Bu-t] promotes efficient coupling for a variety of alc. nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand I [R = adamantyl, R’ = cyclohexyl] was developed to improve these challenging C-O bond-forming reactions. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H9NO