Zhang, Huiping published the artcileSynthesis of 2-cyanoacrylates containing pyridinyl moiety under ultrasound irradiation, COA of Formula: C6H7ClN2, the main research area is pyridinylaminocyanoacrylate preparation antitumor; cyanoacrylate pyridinylamino preparation antitumor; methylthiocyanoacrylate pyridinamine substitution ultrasound.
Reaction of NCCH2CO2Et with CS2 and Me2SO4 in the presence of NaOMe in anhydrous MeOH yields 2-cyano-3,3-bis(methylthio)acrylate. Further nucleophilic substitution with 3-amino-2-chloro-4-methylpyridine under ultrasonic irradiation afforded 3-[(2-chloro-4-methylpyridin-3-yl)amino]-2-cyano-3-methylthioacrylate as key intermediate. The title compounds were then obtained through the reaction of the key intermediate with primary aliphatic amines under reflux. All new structures were verified by elemental anal., IR, 1H NMR and mass spectra. In the MTT test, the compounds were found to possess moderate antitumor activities against PC3 and A431 cells.
Journal of Heterocyclic Chemistry published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, COA of Formula: C6H7ClN2.