Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-Like protease based on phthalhydrazide ketones or heteroaromatic esters was written by Zhang, Jianmin;Pettersson, Hanna I.;Huitema, Carly;Niu, Chunying;Yin, Jiang;James, Michael N. G.;Eltis, Lindsay D.;Vederas, John C.. And the article was included in Journal of Medicinal Chemistry in 2007.Name: 3-Hydroxy-6-methyl-2-nitropyridine This article mentions the following:
The 3C-like protease (3CLpro), which controls the severe acute respiratory syndrome (SARS) coronavirus replication, has been identified as a potential target for drug design in the treatment of SARS. A series of tetrapeptide phthalhydrazide ketones, pyridinyl esters, and their analogs have been designed, synthesized, and evaluated as potential SARS 3CLpro inhibitors. Some pyridinyl esters, e.g., I, were identified as very potent inhibitors, with IC50 values in the nanomolar range (50-65 nM). Electrospray mass spectrometry indicated a mechanism involving acylation of the active site cysteine thiol for this class of inhibitors. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Name: 3-Hydroxy-6-methyl-2-nitropyridine).
3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 3-Hydroxy-6-methyl-2-nitropyridine