At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Application In Synthesis of 16133-25-8.
Zhang, Jiawei;Kong, Kaimin;Li, Xiangjun;Zhang, Qian research published 《 Kemp-type elimination of 1-arylsulfonyl-3-iodo-1H-indazoles》, the research content is summarized as follows. An intriguing ring-opening reaction of 1-arylsulfonyl-3-iodo-1H-indazoles, which can afford the corresponding ortho-(arylsulfonylamino)benzonitriles under base catalysis, was obtained unexpectedly. Herein, the optimal reaction conditions were explored and the results showed that high temperature and aprotic polar solvent are favorable to the ring-opening reaction. Most of the substrates studied can provide the corresponding ring-opening products in moderate to good yields after stirring in DMSO with K2CO3 at 120°C for 18 h, suggesting the excellent compatibility of functional groups and the broad substrate scope of this reaction. Furthermore, the control experiments implied that 1-arylsulfonyl-3-iodoindazoles go through an E2 elimination mechanism similar to Kemp elimination.
16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Application In Synthesis of 16133-25-8