Zhang, Jing-Tao; Wang, Li-Xia; Yang, Feng-Min; Yang, Luo; Liu, Yan; Tang, Ya-Lin published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Selective recognition of DNA parallel G-quadruplexes by 3,8a-disubstituted indolizinones》.Synthetic Route of C7H5N The article contains the following contents:
Owing to its potential biol. relevance, DNA G-quadruplex has been considered as a prospective anti-cancer target. Some known G-quadruplex-interactive N-containing compounds with low cytotoxicity have become prospective anticancer drugs. Here we reported a new type of N-containing alkaloids 3,8a-disubstituted indolizinones, and investigated their substituent effects at 3- and 8a-positions in targeting to DNA c-myc G-quadruplex. And then we used 3-naphtyl-8a-(pyridin-2-yl) substrate I8 as an example, and investigated its ability in targeting to DNA parallel G-quadruplexes in vitro. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Synthetic Route of C7H5N)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Synthetic Route of C7H5N