Zhang, Lin; Fan, Junhua; Chong, Jer-Hong; Cesena, Angela; Tam, Betty Y. Y.; Gilson, Charles; Boykin, Christina; Wang, Deping; Aivazian, Dikran; Marcotte, Doug; Xiao, Guangqing; Le Brazidec, Jean-Yves; Piao, Jinhua; Lundgren, Karen; Hong, Kevin; Vu, Khang; Nguyen, Khanh; Gan, Liang-Shang; Silvian, Laura; Ling, Leona; Teng, Min; Reff, Mitchell; Takeda, Nicole; Timple, Noel; Wang, Qin; Morena, Ron; Khan, Samina; Zhao, Shuo; Li, Tony; Lee, Wen-Cherng; Taveras, Arthur G.; Chao, Jianhua published the artcile< Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)>, Related Products of 220731-04-4, the main research area is pyrazolopyrimidine sulfonamide preparation multiple mitotic kinase inhibitor.
A novel class of pyrazolopyrimidine-sulfonamides was discovered as selective dual inhibitors of aurora kinase A (AKA) and cyclin-dependent kinase 1 (CDK1). These inhibitors were originally designed based on an early lead (compound I). SAR development has led to the discovery of potent inhibitors with single digit nM IC50s towards both AKA and CDK1. An exemplary compound II has demonstrated good efficacy in an HCT116 colon cancer xenograft model.
Bioorganic & Medicinal Chemistry Letters published new progress about Alkylation. 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Related Products of 220731-04-4.