Zhang, Sheng; Li, Lijun; Li, Jingjing; Shi, Jianxue; Xu, Kun; Gao, Wenchao; Zong, Luyi; Li, Guigen; Findlater, Michael published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Electrochemical Arylation of Aldehydes, Ketones, and Alcohols: from Cathodic Reduction to Convergent Paired Electrolysis》.Electric Literature of C6H4N2 The article contains the following contents:
Arylation of carbonyls, one of the most common approaches toward alcs., has received tremendous attention, as alcs. are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochem. arylation can fill the gap. By taking advantage of synthetic electrochem., com. available aldehydes (ketones) and benzylic alcs. can be readily arylated to provide a general and scalable access to structurally diverse alcs. (97 examples, >10 g-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochem. technol., was employed to transform low-value alcs. into more useful alcs. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral α-arylation of benzylic alcs. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C6H4N2