Zhang, Tony Y. published the artcileRegioselective synthesis of 2-chloro-3-pyridinecarboxylates, COA of Formula: C6H7ClN2, the main research area is chloropyridinecarboxylate regioselective preparation; pyridinecarboxylate chloro regioselective preparation.
2-Chlorocyanoacetate undergoes base-catalyzed Michael addition to α,β-unsaturated ketones or aldehydes, e.g., acrolein, to afford 5-oxopentenenitrile derivatives, e.g., OHCCH2CH2CCl(CN)CO2Et. In the presence of anhydrous HCl, these compounds cyclize to yield 2-chloro-3-pyridinecarboxylates, e.g., I. The process is highly regiospecific and useful in the synthesis of 2,3-disubstituted pyridines.
Tetrahedron published new progress about chloropyridinecarboxylate regioselective preparation; pyridinecarboxylate chloro regioselective preparation. 133627-45-9 belongs to class pyridine-derivatives, name is 2-Chloro-4-methylpyridin-3-amine, and the molecular formula is C6H7ClN2, COA of Formula: C6H7ClN2.