The author of 《Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions》 were Zhang, Xitao; Feng, Xiujuan; Zhang, Haixia; Yamamoto, Yoshinori; Bao, Ming. And the article was published in Green Chemistry in 2019. Related Products of 3510-66-5 The author mentioned the following in the article:
A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines I [R = H, 6-Me, 4-Br, etc.; R1 = Cl, Br] was described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation was operationally simple and exhibited high functional-group tolerance. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 3510-66-5