Zhang, Xuan; McNally, Andrew published the artcile< Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts>, Application of C10H6Cl2N2, the main research area is alkylheterocycle regioselective preparation; heterocyclic phosphonium salt preparation organozinc alkylation cobalt catalyst; alkyl Negishi; alkylation; cobalt-catalysis; cross-coupling; late-stage; phosphonium salts; pyridines.
Alkylated pyridines are common in pharmaceuticals, and metal catalysis is frequently used to prepare this motif via Csp2-Csp3 coupling processes. We present a cobalt-catalyzed coupling reaction between pyridine phosphonium salts and alkylzinc reagents that can be applied to complex drug-like fragments and for late-stage functionalization of pharmaceuticals. The reaction generally proceeds at room temperature, and 4-position pyridine C-H bonds are the precursors in this strategy. Given the challenges in selectively installing (pseudo)halides in complex pyridines, this two-step process enables sets of mols. to be alkylated that would be challenging using traditional cross-coupling methods.
ACS Catalysis published new progress about Alkylation. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Application of C10H6Cl2N2.