Zhang, Xuqing published the artcileOptimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors, HPLC of Formula: 844501-00-4, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(16), 4762-4767, database is CAplus and MEDLINE.
A series of indazoles, e.g. I–III, have been discovered as KHK inhibitors from a pyrazole hit identified through fragment-based drug discovery (FBDD). The optimization process guided by both X-ray crystallog. and solution activity resulted in lead-like compounds with good pharmaceutical properties.
Bioorganic & Medicinal Chemistry Letters published new progress about 844501-00-4. 844501-00-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Boronic Acids,Boronic acid and ester, name is (1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)boronic acid, and the molecular formula is C31H25F2N5O7S, HPLC of Formula: 844501-00-4.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem