Zhang, Yongliang’s team published research in Tetrahedron Letters in 34 | CAS: 636-73-7

Zhang, Yongliang published the artcileN-alkylation of pyridylalanine and pyridinecarboxylic acids and their use in synthesis of GnRH antagonists, Synthetic Route of 636-73-7, the publication is Tetrahedron Letters (1993), 34(23), 3659-62, database is CAplus.

A mild N-alkylation method has been developed for the synthesis of N-alkylated pyridiniumcarboxylic acids using Ag₂O-H₂O catalysis to enhance the low reactivity of pyridinecarboxylic acids. Two approaches were undertaken for the synthesis of a series of GnRH antagonists containing pyridinium moieties at the side chain: (1) incorporation of alkylated D-pyridylalanine analogs I (Boc = Me₃CO₂C; R = Me, CH₂Ph, CHMe₂, Bu) during solid phase peptide chain assembly, and (2) coupling of the N-alkylated pyridiniumcarboxylic acid to a D-lysine ε-amino group on a solid support.

Tetrahedron Letters published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C18H35NO, Synthetic Route of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem