Zhang, Yong published the artcileDiscovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents, HPLC of Formula: 39856-58-1, the publication is ACS Medicinal Chemistry Letters (2018), 9(11), 1117-1122, database is CAplus and MEDLINE.
The multi-functional cytokine TGFβ plays a central role in regulating antitumor immunity. It has been postulated that inhibition of TGFβ signaling in concert with checkpoint blockade will provide improved and durable immune response against tumors. Herein, we describe a novel series of 4-azaindole TGFβ receptor kinase inhibitors with excellent selectivity for TGFβ receptor 1 kinase. The combination of compound 3f and an antimouse-PD-1 antibody demonstrated significantly improved antitumor efficacy compared to either treatment alone in a murine tumor model.
ACS Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C39H35N5O8, HPLC of Formula: 39856-58-1.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem