In 2013,Zhang, Yuanyuan; Yang, Weiqing; Xu, Keping; Ma, Menglin; Wang, Yuliang published 《Synthesis and antibacterial activities of pleuromutilin derivatives containing aryl urea groups》.Letters in Drug Design & Discovery published the findings.Safety of 6-Bromopyridin-3-amine The information in the text is summarized as follows:
A series of novel pleuromutilin derivatives containing aryl urea groups was synthesized and their antibacterial activity was evaluated in vitro against Staphylococcus aureus ATCC 26113, Staphylococcus aureus SC, Staphylococcus albus ATCC 8799 and Pseudomonas aeruginosa ATCC 27853. Most of compounds exhibited more potent activities than reference drug Tiamulin against Staphylococcus aureus ATCC 26113 and Saphylococcus aureus SC. Several compounds containing a pyridine urea group and a compound with a quinoline urea group showed excellent activity with the MIC value less than 0.001 μg/mL against Staphylococcus aureus SC. The title compounds thus formed included a thioether urea pyridine derivative (I) and related substances. The synthesis of the target compounds was achieved by a reaction of 2-[(2-amino-1,1-dimethylethyl)thio]acetic acid 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester with 2,2,2-trichloro-N-phenylacetamide derivatives and analogs. In the experiment, the researchers used 6-Bromopyridin-3-amine(cas: 13534-97-9Safety of 6-Bromopyridin-3-amine)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 6-Bromopyridin-3-amine