Zhang, Yue-Mei published the artcileSyntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs), Recommanded Product: 2-Methoxynicotinaldehyde, the main research area is heterocyclic arylsulfone derivative preparation matrix metalloproteinase inhibitor.
Several classes of arylsulfone-based MMP-2/-9 inhibitors utilizing 6- to 8-membered heterocyclic rings, e.g., I, as zinc-binding groups (ZBGs) have been synthesized and their enzyme inhibitory activities were evaluated. Although a number of 6- and 7-membered heterocycles were effective, the most potent arylsulfone inhibitors are based on the rigid 1- or 3-hydroxypyridone ZBG.
Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship, metalloproteinase-inhibiting. 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, Recommanded Product: 2-Methoxynicotinaldehyde.