Assessing the neurotoxicity of airborne nano-scale particulate matter in human iPSC-derived neurons using a transcriptomics benchmark dose model was written by Zhang, Zhengbao;Li, Xiang;Jiang, Shuyun;Qiu, Chunfang;Guo, Ping;Wang, Ziwei;Xu, Chi;Zhang, Liying;Ma, Xingyu;Chen, Shen;Xing, Xiumei;Chen, Liping;Wang, Qing;Ma, Huimin;Zeng, Xiaowen;Chen, Wen;Li, Daochuan. And the article was included in Toxicology and Applied Pharmacology in 2022.Related Products of 54-47-7 The following contents are mentioned in the article:
Airborne nano-scale particulate matter (nPM) exposure is a risk factor for neurol. diseases. However, to date, there has been no comprehensive evaluation of ambient nPMs neurotoxicity. We examined the toxic effects of nPM on human neurons derived from induced pluripotent stem cells (iPSCs) at doses ranging from 0 to 200μg/mL, and employed whole-genome RNA-sequencing in different dose groups to gain further insight into the neurotoxicity of ambient nPM. Our findings showed that nPM was absorbed by neurons, and induced a variety of toxic effects. The apical benchmark dose lower confidence bound (aBMDL) values of each effect endpoint were ranked as follows, in ascending order: mitochondrial membrane potential, neurite length, early apoptosis, cell viability. BMD anal. based on transcriptomic data revealed that the point of departure (PoD) of the 20 pathways with the lowest p-values (0.75μg/mL), the top 20 upstream regulators (0.79μg/mL) and the neurol. diseases (0.77μg/mL) could be appropriate for nPM neurotoxicity evaluation. The transcriptomic PoDs (tPoDs) were similar to apical PoDs (aPoDs) since their absolute fold differences were within 10-fold. Further anal. of the transcriptomic data revealed that nPM exposure could disturb the pathways related to ferroptosis, neurotransmitters, xenobiotic metabolism, etc., which might be critical in regulating nPM neurotoxicity. We also found that low-dose nPM induced cytokine signaling pathways, while high doses of nPM activated cell-cycle regulation and DNA repair pathways. Our results indicate that BMD modeling based on transcriptomic data could be useful in illustrating the neurotoxic mechanism, and also could be a promising method for evaluating the potential health risks of nPM. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Related Products of 54-47-7).
(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 54-47-7