Zhao, Changgui; Ye, Zhengqing; Ma, Zhi-xiong; Wildman, Scott A.; Blaszczyk, Stephanie A.; Hu, Lihong; Guizei, Ilia A.; Tang, Weiping published the artcile< A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings>, HPLC of Formula: 3731-53-1, the main research area is polycyclic steroid preparation oxidation ring expastion natural product.
The interrogation of complex biol. pathways demands diverse small mol. tool compounds, which can often lead to important therapeutics for the treatment of human diseases. Since natural products are the most valuable source for the discovery of therapeutics, the derivatization of natural products has been extensively investigated to generate mols. for biol. screenings. However, most previous approaches only modified a limited number of functional groups, which resulted in a limited number of skeleta. Here, a general strategy for the preparation of a library of complex small mols. by combining state-of-the-art chem. – the site-selective oxidation of C-H bonds – with reactions that expand rigid, small rings in polycyclic steroids to medium-sized rings is described. This library occupies a unique chem. space compared to selected diverse reference compounds The diversification strategy developed herein for steroids can also be expanded to other types of natural products.
Nature Communications published new progress about Alkylation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.