Zhao, Hong-Wu; Li, Hai-Long; Yue, Yuan-Yuan; Sheng, Zhui-Hui published an article in 2013, the title of the article was Diastereoselective and Enantioselective Michael Addition Reactions of Ketones and Aldehydes to Nitro Olefins Catalyzed by C2-Symmetric Axially-Unfixed Biaryl-Based Organocatalysts Derived from Enantiopure α-Proline.Reference of [2,2′-Bipyridine]-3,3′-diamine And the article contains the following content:
A new class of axially-unfixed biaryl-based pyrrolidines with C2-symmetry, e.g. I [X = C, N], were designed and synthesized by using enantiopure α-proline as a chiral source. These bifunctional organocatalysts provided Michael adducts in high chem. yields (up to 99 %) and with excellent stereoselectivities (up to 99:1 dr and 96 % ee) in the direct Michael addition reactions of a variety of ketones and aldehydes to nitro olefins. The transition states were proposed to clarify the stereochem. course of the examined reactions. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Reference of [2,2′-Bipyridine]-3,3′-diamine
The Article related to preparation biaryl pyrrolidine c 2 symmetry michael addition catalyst, stereoselective michael addition ketone aldehyde nitro olefin, General Organic Chemistry: Synthetic Methods and other aspects.Reference of [2,2′-Bipyridine]-3,3′-diamine