In 2017,Zhao, Huai-Bo; Liu, Zhan-Jiang; Song, Jinshuai; Xu, Hai-Chao published 《Reagent-Free C-H/N-H Cross-Coupling: Regioselective Synthesis of N-Heteroaromatics from Biaryl Aldehydes and NH3》.Angewandte Chemie, International Edition published the findings.Quality Control of 2-Bromonicotinaldehyde The information in the text is summarized as follows:
An unprecedented synthesis of N-heteroaromatics from biaryl aldehydes and NH3 through reagent-free C-H/N-H cross-coupling has been developed. The electrosynthesis uses NH3 as an inexpensive and atom-economic nitrogen donor, requires no oxidizing agents, and allows efficient and regioselective access to a wide range of phenanthridines and structurally related polycyclic N-heteroaromatic products. Thus, e.g., oxidative condensation of aldehyde I with NH3 in an undivided cell using reticulated vitreous carbon anode and Pt cathode in an HFIP/MeOH solvent system afforded phenanthridine II (94%). In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-Bromonicotinaldehyde