Zhao, Zhijian published the artcileSynthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors, COA of Formula: C5H6BNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(12), 2952-2956, database is CAplus and MEDLINE.
A series of N-heterocyclic pyridinone catechol-O-methyltransferase (COMT) inhibitors were synthesized. Physicochem. properties, including ligand lipophilic efficiency (LLE) and clog P, were used to guide compound design and attempt to improve inhibitor pharmacokinetics. Incorporation of heterocyclic central rings provided improvements in physicochem. parameters but did not significantly reduce in vitro or in vivo clearance. Nevertheless, compound I was identified as a potent inhibitor with sufficient in vivo exposure to significantly affect the dopamine metabolites homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC), and indicate central COMT inhibition.
Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C18H24N6O6S4, COA of Formula: C5H6BNO2.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem