On July 15, 2022, Zhen, Guangjin; Wang, Furong; Yin, Biaolin published a patent.Electric Literature of 2229858-27-7 The title of the patent was Preparation of cyclobutane fused spiro indoline compounds as antitumor agents. And the patent contained the following:
The invention discloses the preparation of cyclobutane fused spiro indoline compounds with general formula I or II as antitumor agents [where X=O, S, CH = CH; R1=H, halogen group, ether group, aryl, siloxane or alkyl; R2=alkyl, siloxane, alkynyl or heterocyclic; R3=acetyl, p-methoxybenzyl, methylthiomethyl, tervaleryl, benzyloxycarbonyl, tert butoxycarbonyl, benzyl or p-methoxyphenyl], which has the advantages of simple preparation method, mild conditions, environmental protection and suitable for large-scale preparation For example, compound I (X=S, R1=H, R2=CH2CH2OCH3, R3=Ac) was prepared by photocatalytic cyclization of 1-acetyl-N-(2-methoxyethyl)-N-(thiophen-2-ylsulfonyl)-1H-indole-2-carboxamide. The title compounds have good inhibitory activity on hcc1806 cells and can be used to prepare anticancer agents. The experimental process involved the reaction of 4,4′-Bis(trifluoromethyl)-2,2′-bipyridinebis[3,5-difluoro-2-[5-methyl-2-pyridinyl)phenyl] iridium(III) hexafluorophosphate(cas: 2229858-27-7).Electric Literature of 2229858-27-7
The Article related to photocatalysis cyclization fused indoline isothiazole preparation treatment human cancer, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 2229858-27-7