Zheng, Danqing; Studer, Armido published the artcile< Asymmetric Synthesis of Heterocyclic γ-Amino-Acid and Diamine Derivatives by Three-Component Radical Cascade Reactions>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is asym synthesis heterocyclic amino acid diamine multicomponent radical cascade; Brønsted acids; amino acids; asymmetric synthesis; photochemistry; radicals.
An enantioselective three-component radical reaction of quinolines or pyridines with enamides and α-bromo carbonyl compounds by dual photoredox and chiral Bronsted acid catalysis is presented. A range of valuable chiral γ-amino-acid derivatives are accessible in high chemo-, regio-, and enantioselectivity from simple, readily available starting materials under mild reaction conditions. Using the same strategy, the asym. synthesis of 1,2-diamine derivatives is also reported. Thus, e.g., 4-methylquinoline + N-vinylacetamide + Me bromoacetate → I (88%, 96:4 er).
Angewandte Chemie, International Edition published new progress about Carbonyl compounds (organic), halo carbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent) (quinoline/pyridine + N-vinylacetamide + α-bromo carbonyl compound → γ-amino acid). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.