Zheng, Meng; Jiang, Tong; Yang, Wen; Zou, Yan; Wu, Haigang; Liu, Xiuhua; Zhu, Fengping; Qian, Rongjun; Ling, Daishun; McDonald, Kerrie; Shi, Jinjun; Shi, Bingyang published the artcile< The siRNAsome: A Cation-Free and Versatile Nanostructure for siRNA and Drug Co-delivery>, Application of C10H8N2S2, the main research area is siRNAsome nanostructure siRNA drug codelivery; co-delivery; nanostructures; siRNA; synergistic therapy; vesicles.
Nanoparticles show great potential for drug delivery. However, suitable nanostructures capable of loading a range of drugs together with the co-delivery of siRNAs, which avoid the problem of cation-associated cytotoxicity, are lacking. Herein, we report an small interfering RNA (siRNA)-based vesicle (siRNAsome), which consists of a hydrophilic siRNA shell, a thermal- and intracellular-reduction-sensitive hydrophobic median layer, and an empty aqueous interior that meets this need. The siRNAsome can serve as a versatile nanostructure to load drug agents with divergent chem. properties, therapeutic proteins as well as co-delivering immobilized siRNAs without transfection agents. Importantly, the inherent thermal/reduction-responsiveness enables controlled drug loading and release. When siRNAsomes are loaded with the hydrophilic drug doxorubicin hydrochloride and anti-P-glycoprotein siRNA, synergistic therapeutic activity is achieved in multidrug resistant cancer cells and a tumor model.
Angewandte Chemie, International Edition published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.