Zhong, Lili published the artcileSynthesis of deuterium-enriched sorafenib derivatives and evaluation of their biological activities, Application In Synthesis of 24484-93-3, the main research area is sorafenib deuterium anticancer agent cervical carcinoma; Antitumor activities; Deuterium substitution; Pharmacokinetics; Sorafenib.
Deuterium substitution has been widely known that can improve the pharmacokinetic profiles due to isotope effect. Herein, a series of deuterated sorafenib derivatives have been synthesized and characterized by 1H NMR, 13C NMR and MS. Their antitumor activities were evaluated in vitro against human hepatoma cell line HepG2 and human cervical carcinoma cell line HeLa. The LogP values were detected by high-performance liquid chromatog. Subsequently, the metabolic stability and pharmacokinetics study were assessed in vitro and in vivo.
Molecular Diversity published new progress about Antitumor agents. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Application In Synthesis of 24484-93-3.