Application In Synthesis of 4-CyanopyridineIn 2020 ,《Benzylic C-H heteroarylation of N-(benzyloxy)phthalimides with cyanopyridines enabled by photoredox 1,2-hydrogen atom transfer》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Zhong, Long-Jin; Wang, Hong-Yu; Ouyang, Xuan-Hui; Li, Jin-Heng; An, De-Lie. The article conveys some information:
A visible light initiated α-C(sp3)-H arylation of N-(benzyloxy)phthalimides with cyanopyridines for the construction of highly valuable pyridinyl-containing diarylmethanols, including bioactive motif-based analogs, is reported. This method enables arylation of the C(sp3)-H bonds adjacent to an oxygen atom through alkoxy radical formation by O-N bond cleavage, 1,2-hydrogen atom transfer (HAT), arylation and C-CN bond cleavage cascades, and offers a means to exploit 1,2-HAT modes to incorporate functional groups for constructing functionalized alcs. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)
4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 4-Cyanopyridine