Zhou, Sen; Sun, Ze-Ying; Zhu, Kongying; Zhao, Wentao; Tang, Xiangyang; Guo, Minjie; Wang, Guangwei published the artcile< Metal-Free Difunctionalization of Pyridines: Selective Construction of N-CF2H and N-CHO Dihydropyridines>, Quality Control of 350-03-8, the main research area is pyridine nitroalkane bromodifluoroacetate regioselective nucleophilic addition; nitroalkyl difluoromethyl dihydropyridine preparation; nitromethylene difluoromethyl dihydropyridine preparation; formyl difluoromethyl dihydropyridine preparation.
A novel nucleophilic addition of N-difluoromethylpyridinium salts with nitroalkanes to synthesize N-CF2H-dihydropyridines and N-CHO-dihydropyridines in a highly efficient and regioselective pathway was reported. This protocol exhibited good functional group tolerance and good to excellent yields.
Organic Letters published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Quality Control of 350-03-8.