Zhou, Su; Li, Rui; Zhang, Zhichao; Gu, Minyang; Zhu, Hongyan; Fang, Jing; Ji, Zhiwen; Xu, Xiaodong; Tang, Liming published an article in 2021. The article was titled 《Analysis of mutagenic components of oxidative hair dyes with the Ames test》, and you may find the article in Human & Experimental Toxicology.Application In Synthesis of 2,6-Diaminopyridine The information in the text is summarized as follows:
Oxidative hair dyes consist of two components (I and II) that are mixed before use. Aromatic amines in component I and their reaction with hydrogen peroxide after mixing them with component II have been of primary concern. In addition, two in vitro genotoxicity assays are still required for the approval of the final products of oxidative hair dyes in China, and the substance in the oxidative hair dye that causes the high rate of pos. results in genotoxicity tests, especially the Ames test, has not been fully elucidated. In this study, we analyzed the formulation of 55 different oxidative hair dyes from 7 color series and performed Ames tests in the strain TA98 with the S9 mix (oxidative hair dyes Number 1-30) and in strain TA97a without the S9 mix (oxidative hair dyes Number 31-55). We found that toluene-2,5-diamine sulfate (2,5-diaminotoluene sulfate, DATS) in component I may be the cause of mutagenicity in TA98, and hydrogen peroxide in component II may be the cause of mutagenicity in TA97a, and their pos. concentrations were consistent with those that we calculated from Ames tests. The results suggest that the pos. results for the oxidative hair dye in the Ames test were inevitable because of the existence of DATS in component I and of hydrogen peroxide in component II. Therefore, we should carry out safety assessments on each raw material and carry out risk assessments on the final products of oxidative hair dyes instead of genotoxicity tests in China. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)
2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine