Zhu, Guohua; Huang, Yang; Wang, Chun; Lu, Linxia; Sun, Tongming; Wang, Miao; Tang, Yanfeng; Shan, Doudou; Wen, Shuijin; Zhu, Jinli published the artcile< A novel coumarin-based fluorescence chemosensor for Al3+ and its application in cell imaging>, Reference of 93-60-7, the main research area is coumarin fluorescence chemosensor aluminum cell imaging; Al(3+); Chemosensor; Coumarin; Live cells.
As an efficient turn-on fluorescent chemosensor for Al3+, a new coumarin derivative (CND) has been designed and synthesized by the condensation of 8-formyl-7-hydroxycoumarin with niacin hydrazide. The spectroscopic studies revealed that the sensor CND exhibited a remarkable fluorescence enhancement towards Al3+ with high selectivity and sensitivity in EtOH-HEPES (95:5, volume/volume, pH = 7.40), which was attributed to the photoinduced electron transfer (PET) and -C:N isomerization mechanism. Fluorescence titration calculations data showed that the detection limit and the association constants of CND for Al3+ are 2.51 × 10-7 M and 9.64 × 104 M-1, resp. The results of experiments, including Job’s plot, 1H NMR titration and ESI-MS, revealed that the stoichiometric binding between CND and Al3+ was 1:1. The studies of the pH dependency of CND for Al3+ detection, and the cell imaging suggested the sensor CND could be promisingly applied for the recognition of Al3+ in biol. cells.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Fluorescence. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.