In 2017,Zhu, Xue-Qing; Mao, Shuai; Guo, Dong-Dong; Li, Bin; Guo, Shi-Huan; Gao, Ya-Ru; Wang, Yong-Qiang published 《Copper-Catalyzed Isomerization and Cyclization of E/Z-o-Haloaryl N-Sulfonylhydrazones: Convenient Access to 1H-Indazoles》.ChemCatChem published the findings.Formula: C6H4BrNO The information in the text is summarized as follows:
A new isomerization approach is presented, namely a copper-catalyzed C=N double bond isomerization of hydrazones, which is followed by an efficient intramol. C-N coupling reaction, providing an unprecedented catalytic approach for the synthesis of 1H-indazoles, e.g., I, from readily accessible Z/E mixture of o-haloaryl N-sulfonylhydrazones, e.g., II.2-Bromonicotinaldehyde(cas: 128071-75-0Formula: C6H4BrNO) was used in this study.
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C6H4BrNO